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A total of three % of Lively compound is excreted in urine as unchanged active material. Tapentadol is On top of that metabolised to N-desmethyl tapentadol (13 %) by CYP2C9 and CYP2C19 and also to hydroxy tapentadol (two %) by CYP2D6, which happen to be even more metabolised by conjugation. Therefore, Lively material metabolism mediated by cytochro